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James C Paton Selected Research

Melanoma (Melanoma, Malignant)

1/2023Serum Neu5Gc biomarkers are elevated in primary cutaneous melanoma.
9/2012The Escherichia coli subtilase cytotoxin A subunit specifically cleaves cell-surface GRP78 protein and abolishes COOH-terminal-dependent signaling.
10/2010Targeting GRP78 to enhance melanoma cell death.

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James C Paton Research Topics

Disease

57Infections
04/2024 - 04/2002
28Pneumococcal Infections
11/2021 - 07/2002
15Hemolytic-Uremic Syndrome
01/2021 - 04/2002
9Neoplasms (Cancer)
01/2023 - 11/2009
9Pneumonia (Pneumonitis)
11/2021 - 08/2003
8Inflammation (Inflammations)
01/2019 - 01/2008
7Sepsis (Septicemia)
10/2015 - 08/2003
7Necrosis
08/2013 - 07/2004
5Meningitis
01/2022 - 06/2012
5Bacterial Infections (Bacterial Infection)
01/2019 - 09/2007
5Autolysis
01/2017 - 09/2008
5Pneumococcal Pneumonia
06/2012 - 08/2003
4Breast Neoplasms (Breast Cancer)
01/2023 - 01/2016
4Hepatocellular Carcinoma (Hepatoma)
12/2018 - 08/2009
4Diarrhea
01/2016 - 08/2009
3Melanoma (Melanoma, Malignant)
01/2023 - 10/2010
3Disease Progression
01/2022 - 06/2012
3Communicable Diseases (Infectious Diseases)
01/2021 - 08/2008
3Human Influenza (Influenza)
01/2019 - 01/2017
3Thrombosis (Thrombus)
11/2010 - 07/2004
2Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis)
01/2023 - 04/2017
2Lung Injury
01/2023 - 07/2004
2Type 2 Diabetes Mellitus (MODY)
11/2022 - 11/2019
2Ovarian Neoplasms (Ovarian Cancer)
03/2022 - 12/2019
2Acute Kidney Injury (Acute Renal Failure)
11/2019 - 01/2014
2Acute Lung Injury
01/2019 - 12/2012
2Bacterial Pneumonia
01/2019 - 11/2011
2Osteosarcoma (Osteogenic Sarcoma)
12/2018 - 11/2017
2Starvation
11/2017 - 01/2014
2Whooping Cough (Pertussis)
01/2017 - 10/2006
2Fibrosis (Cirrhosis)
07/2015 - 11/2014
2Atrophy
09/2014 - 04/2011
2Edema (Dropsy)
06/2014 - 08/2013
2Thrombocytopenia (Thrombopenia)
06/2014 - 10/2007
2Hemolytic Anemia
06/2014 - 10/2007
2Cholera
11/2013 - 10/2006
2Experimental Arthritis
04/2011 - 07/2009
2Colitis
08/2009 - 01/2008
2Respiratory Tract Infections (Respiratory Tract Infection)
01/2008 - 07/2006
1Nervous System Diseases (Neurological Disorders)
10/2023
1Intellectual Disability (Idiocy)
10/2023
1Epilepsy (Aura)
10/2023
1Viral Pneumonia
01/2023

Drug/Important Bio-Agent (IBA)

30Proteins (Proteins, Gene)FDA Link
10/2023 - 04/2002
17Streptococcus pneumoniae plY proteinIBA
11/2021 - 07/2002
13Cytotoxins (Cytolysins)IBA
01/2021 - 07/2004
11VaccinesIBA
10/2022 - 08/2003
11Shiga Toxin (Shigella Toxin)IBA
01/2021 - 10/2007
10Endoplasmic Reticulum Chaperone BiPIBA
10/2019 - 01/2008
8AntigensIBA
04/2017 - 08/2003
7CytokinesIBA
11/2022 - 07/2004
7Virulence Factors (Pathogenicity Factors)IBA
11/2021 - 07/2004
6Polysaccharides (Glycans)IBA
10/2022 - 07/2002
6Anti-Bacterial Agents (Antibiotics)IBA
01/2021 - 02/2010
4Biomarkers (Surrogate Marker)IBA
01/2023 - 01/2016
4Complement System Proteins (Complement)IBA
03/2022 - 12/2002
4ZincIBA
10/2020 - 01/2014
4Pneumococcal Vaccines (Pneumococcal Polysaccharide Vaccine)IBA
01/2019 - 06/2012
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2015 - 06/2007
3N-Acetylneuraminic Acid (Sialic Acid)IBA
01/2023 - 07/2009
3SugarsIBA
01/2023 - 01/2020
3RaffinoseIBA
01/2022 - 01/2019
3LigandsIBA
01/2020 - 05/2007
3ThapsigarginIBA
12/2019 - 11/2009
3Carrier Proteins (Binding Protein)IBA
01/2016 - 07/2002
3pneumococcal surface protein AIBA
10/2015 - 07/2002
3AntibodiesIBA
09/2012 - 04/2002
2Oxidoreductases (Dehydrogenase)IBA
04/2024 - 04/2017
2LectinsIBA
01/2023 - 03/2022
2GlycoconjugatesIBA
01/2023 - 01/2018
2Tumor Biomarkers (Tumor Markers)IBA
01/2023 - 03/2022
2ProinsulinIBA
11/2022 - 11/2019
2N-glycolylneuraminic acidIBA
03/2022 - 01/2018
2Peptides (Polypeptides)IBA
01/2022 - 12/2018
2Glucose (Dextrose)FDA LinkGeneric
01/2022 - 10/2019
2CholesterolIBA
11/2021 - 06/2012
2Transcription Factors (Transcription Factor)IBA
10/2021 - 09/2014
2ChemokinesIBA
01/2020 - 04/2011
2DisulfidesIBA
11/2019 - 01/2017
2Nonesterified Fatty Acids (NEFA)IBA
01/2019 - 01/2018
2Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
10/2015 - 11/2011
2Choline (Choline Chloride)IBA
10/2015 - 07/2002
2aluminum sulfate (alum)IBA
10/2015 - 01/2013
2Bortezomib (Velcade)FDA Link
05/2015 - 10/2010
2IronIBA
02/2013 - 10/2005
2flt3 ligand protein (flt3 ligand)IBA
12/2012 - 09/2007
2Molecular Chaperones (Chaperone, Molecular)IBA
09/2012 - 01/2011
2Neuraminidase (Sialidase)IBA
06/2011 - 07/2006
2OligosaccharidesIBA
05/2010 - 03/2006
2CC ChemokinesIBA
04/2009 - 05/2007
2Toll-Like Receptor 4IBA
10/2005 - 02/2003
2Bacterial ToxinsIBA
05/2005 - 07/2004
2Messenger RNA (mRNA)IBA
10/2003 - 07/2002
1hypothiocyanous acidIBA
04/2024
1Oxidants (Oxidizing Agents)IBA
04/2024
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
10/2023
1ProcalcitoninIBA
01/2023

Therapy/Procedure

5Intraperitoneal Injections
03/2017 - 07/2004
4Drug Therapy (Chemotherapy)
10/2021 - 10/2015
4Therapeutics
12/2019 - 11/2011